Omar Macadar

Domicilio laboral: Instituto de Investigaciones Biológicas "Clemente Estable".
División Neurofisiología. Avenida Italia 3318. 11600. Montevideo, Uruguay.
Teléfono: (598-2) 487 5532
Fax: (598-2) 487 5548
E-mail: omacadar@iibce.edu.uy

EDUCACION ACADEMICA

Doctor en Medicina, Facultad de Medicina de la Universidad de la República,  1969

Otros estudios  Post-grado en Universidad de California: 1971-1973

CARGO ACTUAL

Investigador Jefe del Dpto de Neurofisiología, IIBCE, A 16.  Dedicación Total            Fecha de ingreso al cargo: 1979

Encargado, Unidad Asociada Neurofisiología (IIBCE).Instituto de Biología. Facultad de Ciencias.  Ingreso :      1991

Investigador Grado 5 de PEDECIBA. Ingreso:       1988

PROYECTO DE INVESTIGACION ACTUAL

MATERIAL DOCENTE Y DE DIVULGACION

PUBLICACIONES

ROIG, J.A., I.C. BOVE, O. MACADAR, A. GINES AND E. GARCIA-AUSTT. Visual evoked potentials in the wakeful free rat. Acta Neurol. Latinoam. 7:190-198, 1961 .

GINES, A., I.C. BOVE, O. MACADAR, J.A. ROIG AND E. GARCIA-AUSTT. Influence of curarization and anesthetics upon visual evoked response in the rat. Acta Neurol. Latinoam. 9:204-212. 1963. 

MACADAR, O., A. GINES, I.C. BOVE AND E. GARCIA-AUSTT. Effet of habituation, Interference and Association of Stimuli upon the visual evoked response in the rat. Acta Neurol. Latinoam. 9:315-327. 1963. 

BUDELLI, R., P. HANDLER AND O. MACADAR. Correlations using an averaging computer. Acta Neurol. Latinoam. 14:245-247. 1968. 

MACADAR, O., J.A. ROIG, J.M. MONTI AND R. BUDELLI. The functional relationships between septal unit activity and hippocampal theta rhythm. Physiol. Behav. 5:1443-1449. 1970.

MORALES, F.R., J.A. ROIG, J.M. MONTI, O. MACADAR AND R. BUDELLI. Septal unit activity and hippocampal eeg during the sleep-wakefulness cycle of the rat. Physiol. Behav. 6:563-567.  1971. 

MACADAR, O., G.E. WOLFE, D.P. O`LEARY AND J.P. SEGUNDO. Responses of elasmobranch utricle to maintained spatial orientation, Transitions and Jitter. Exp. Brain  Res. 22:1-12. 1975.

MACADAR, O., G.E. WOLFE, R. BUDELLI AND J.P. SEGUNDO. Multivalued Stimulus-Response Relation in the Isolated Elasmobranch Utricle. Biol. Cybernetics 31:111-118. 1978.

BUDELLI, R. AND O. MACADAR. Stato-Acoustic Properties of Utricular Afferents. J. Neurophysiol. 42:1479-1494. 1979.

SUAREZ, H.E., O. MACADAR AND D. CIBILS. Analyse Dynamique de la Pursuite Oculaire Horizontale et son Application Clinique. Rev. Otoneuroophtalmol. 52:143-146. 1980.

SUAREZ, H.E., A. PEREDA, O. MACADAR. The Clinical Value of Phase Relation in Non Predictive Eye Tracking. J. Laryngol. Otol. 97:593-597. 1983.

DAJAS, F., J.M. GAZTELU, C. RODRIGUEZ, O. MACADAR, E. GARCIA-AUSTT. Effets of Curaremimetics on Hippocampal Activity. Exp. Neurol. 79:160-0167. 1983.

TRUJILLO-CENOZ, O., J.A. ECHAGUE, O. MACADAR. Innervation Pattern and Electric Organ Discharge Waveform in Gymnotus carapo. J. Neurobiol. 15:273-282. 1984.

MACADAR, O. AND R. BUDELLI. Mechanisms of Sensory Adaptation in the Isolated Utricle. Exp. Neurol. 86:147-159. 1984.

BUDELLI, R., E. SOTO, M.T., GONZALEZ-ESTRADA AND O. MACADAR. A Spike Generator Model Simulates Utricular Afferents Response to Sinusoidal Vibrations. Biol. Cybern. 54:237-244. 1986. 

VELLUTI, J., A. CAPUTI AND O. MACADAR. Limbic epilepsy induced in the rat by Dendrotoxin, a polypeptide isolated from the green mamba (Dendroaspis angusticeps) venom. Toxicon 25:649-657. 1987.

LORENZO, D., J.C. VELLUTI AND O. MACADAR, Electrophysiological Properties of Abdominal Electrocytes in the Weakly Electric Fish Gymnotus carapo. J.Comp. Physiol. A  162: 141-146. 1988.

MACADAR, O., D. LORENZO AND J.C. VELLUTI. Waveform generation of the Electric Organ Discharge in Gymnotus carapo. II Electrophysiological properties of single electrocytes. J. Comp. Physiol. A. 165: 353-360.1989.

CAPUTI, A., O. MACADAR AND O. TRUJILLO-CENOZ. Waveform generation of the Electric Organ Discharge in Gymnotus carapo. III: The Electrogenic Organ as an Electric Source. J. Comp. Physiol. A. 165: 361-368. 1989.

LORENZO, D., SIERRA, F., SILVA, A. AND MACADAR, O. Spinal mechanisms of electric organ discharge synchronization in Gymnotus carapo. J. Comp. Physiol. A. vol 167.1990

A.PEREDA, O.MACADAR, I.TRABAL, D.CIBILS, J.V.ECHAGUE and R.BUDELLI. Dynamic analysis of the righting reflex in toads; recovery after hemilabyrinthectomy. Restorative Neurology and Neuroscience. 1: 395-402. 1990 

SUAREZ, H., CAFFA, C., and MACADAR, O.  Postural recovery and vestibular habituation in cerebellar patients. Restor. Neurol. Neurosci. 4 (4) 255-259, 1992.(A)

D. LORENZO, F. SIERRA, A. SILVA, O. MACADAR. Spatial Distribution of the medullary command signal within the electric organ of Gymnotus carapo.J. Comp. Physiol A. 173: 221-226. 1993

A. CAPUTI, A. SILVA, O. MACADAR. Electric organ activation in Gymnotus carapo. Spinal origin and peripheral mechanisms. J. Comp. Physiol A. 173: 227-232. 1993.

 A.CAPUTI, O.MACADAR, O.TRUJILLO-CENOZ. Waveform generation in Rhamphichthys rostratus(L) (Teleostei, Gymnotiformes). The electric organ and its spatio-temporal activation pattern. J. Comp. Physiol A 174: 633-642. 1994.

A. CAPURRO, M. REYES-PARADA, J.L. ARDANAZ, R. SILVEIRA, O. MACADAR. Serotonergic control of electric organ discharge in Gymnotus carapo. Role of 5-HT 2A/2C receptor subtypes. Comp. Biochem. Physiol. 109A: 583-591, 1994.

F. SIERRA, D. LORENZO,  O. MACADAR , W. BUÑO. N-type Ca2A  channels mediate transmitter release at the electromotoneuro-electrocyte synapses of the weakly electric fish Gymnotus carapo. Brain Research   683: 215-220,1995

CAPURRO, M. REYES-PARADA, D. OLAZABAL, R. PERRONE, R. SILVEIRA, O. MACADAR. Aggressive behavior and jamming avoidance response in the weakly electric fish Gymnotus carapo. Effects of

3,4 methylendioxymethanphetamine (MDMA). Comp. Biochem. Physiol.. A, 118A:831-840. 1997

A.CAPUTI, A.C. SILVA, O. MACADAR. The EOD of Brachyhipopomus pinnicaudatus. The effect of environmental variables on waveform generation. Brain, Behav. Evol: 52: 148-158. 1998.

Capurro, A; Diambra, L; Lorenzo, D; Macadar, O; Martin, M; Mostaccio, C; Plastino, A; Rozman E; Torres, M; and Velluti , J

Tsallis entropy and cortical dynamics: the analysis of EEG signals. Physica A, vol. 257 :149-155, 1998

Capurro, A; Macadar, O; Perrone, R and Pakdaman,K.

Computational model of the jamming avoidance response in the electric fish Gymnotus carapo. Biosystems  48: 21-27, 1998

Capurro, A; Pakdaman, K; Perrone, R and Macadar, O. Analysis of the jamming avoidance response in the electric fish Gymnotus carapo. Biol. Cybern. volume 80:269-283, 1999.

LORENZO, D., O. MACADAR, J. VELLUTI. - Orígin and propagation of spontaneous electrographic sharp waves in the in vitro turtle brain. A model of neuronal synchronization Clinical Neurophysiology 110: 1535-1544. 1999

Capurro, A; Diambra, L; Lorenzo, D; Macadar, O; Martin, M; Mostaccio, C; Plastino, A; Rozman E; Torres, M; and Velluti , J Human brain dynamics: the analysis of EEG signals with Tsallis information measure. Physica A . Physica A, vol.265: 235-254, 1999

A.C. SILVA, L.QUINTANA, M. GALEANO, P. ERRANDONEA, O. MACADAR. Water temperature sensitivity of EOD waveform in Brachyhipopomus pinnicaudatus in the wild and under captivity. J. Comp. Physiol A.(1999) 185(2): 187-197.

Capurro, A; Longtin, A; Bargarinao, E ; Sato, S; Macadar, O and Pakdaman, K Variability of the electric organ discharge interval in Gymnotus carapo. Biol. Cybern: 84, 309-321, (2001)

ARDANAZ, J.L., A. SILVA, O. MACADAR.- Influence of Water temperature on Gymnotus carapo EOD wave form. J.Comp. Phisiol A (2001): 187:853-864.

Ana Silva, Laura Quintana, José L. Ardanaz, Omar Macadar

- Environmental and hormonal influences upon EOD waveform in gymnotiform

pulse fish. Journal of Physiology Paris 96 473-484 (2002)

C. Magariños-Ascone, J.H. Pazo, O. Macadar and W. Buño.- High frequency stimulation of the subthalamic nucleus silences subthalamic neurons: a possible cellular mechanism in Parkinson treatment: Neuroscience: 2002, 115:4:1109-1117

L.QUINTANA, A. SILVA, N. BEROIS, O. MACADAR. Temperature induces gonadal maturation and affects electrophysiological sexual maturity indicators in Brachyhypopomus pinnicaudatus from the temperate climate. J. Exp. Biol. (2004) , 207: 1843-1853.

F. SIERRA, V. COMAS, W. BUÑO, O. MACADAR: Sodium dependent plateau potentials in the electrocytes of the electric fish Gymnotus carapo J. Comp. Physiol A.

191:1-11, 2005

D. LORENZO & O.MACADAR: The influence of temperature and reproductive state upon de the Jamming Avoidance Response in the pulse-type electric fish Brachyhypopomus pinnicaudatus.  J. comp.. Physiol  A 191:85-94, 2005

Capítulos de libros

BUDELLI, R. AND O. MACADAR. Dynamic Properties from Utricular Afferents. In Vestibular Function and Morphology. Edited by T. Gualtierotti. Springer-Verlag. New York. 1981.

SUAREZ, H. Y O. MACADAR. Comportamiento del seguimiento ocular con estímulo no predecible. Cap. 8 en C. Gavilán: Fisiología y fisiopatología del Sistema Oculo-motor. Garsí. Madrid. 1987. 

MACADAR, O. AND H.SUAREZ: Fisiología de los receptores vestibulares. En Neurootología:     Ed., Corbera y Suárez  1990

MACADAR, O., PEREDA, A.  Studies of neural plasticity in the vestibular system.  Workshop of Fundamental Neurobiogy.  Editors: Elio García-Austt, Omar Macadar, Omar Trujillo-Cenóz and Ricardo Velluti, Universidad de la República, Montevideo, Uruguay, 1992 

D.LORENZO, A. SILVA, A. CAPUTI, M. BORDE, O. MACADAR. Electrogeneration in South American  Weakly Electric Fish. En: Sensory Biology of Jawed Fish (B.G. Kapoor, T.J. Hara, Eds.) Oxford & IBH Pub., New Delhi, 2001

A.CAPUTI, B. CARLSON & O. MACADAR. Electric organs and their control. En: Electroreception (T. Bullock, C. Hopkins, A. Popper, R. Fay, Eds.) Springer Handbook of Auditory Physiology, Springer, New York, 2005

D. LORENZO, A. SILVA, O. MACADAR. Electrocommunication in Gymnotiformes: Jamming avoidance and  social signals during courtship.  En: Fish Communication  (F. Ladich, S.P. Collin, P. Moller, B.G. Kapoor, Eds) 2005 (en prensa).